A review of the prescribing trend of thiazide-type and thiazide-like diuretics in hypertension: A UK perspective

18Citations
Citations of this article
66Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Thiazide diuretics have been the cornerstone of hypertension treatment for >5 decades. Most recent European and American guidelines recommend both thiazide-type and thiazide-like diuretics as first-line drugs for all patients with hypertension. In contrast, diuretics are not regarded as first-line treatment in the UK and in patients who are to be initiated on a diuretic treatment, thiazide-like molecules, such as chlortalidone and indapamide are the preferred option. This review examines the prescribing trend of the 4 most commonly prescribed thiazide diuretics for the treatment of hypertension in the UK. Prescription cost analysis data were obtained for both 2010 and 2016/2017 for each region of the UK to analyse the impact of the 2011 National Institute for Health and Care Excellence hypertension guidelines on the trend in thiazide diuretic prescribing. Overall, the prescriptions of thiazide diuretics declined over the years. Bendroflumethiazide is the most commonly prescribed diuretic in the UK and despite some geographical differences, thiazide-type diuretics are more widely used than thiazide-like. The use of indapamide increased significantly between 2010 and 2016/2017 while chlortalidone was rarely employed. Of the many factors affecting trends in prescriptions, clinical inertia, treatment adherence, availability of the products and the lack of fixed dose combinations may play a role.

References Powered by Scopus

2018 ESC/ESH Guidelines for themanagement of arterial hypertension

7750Citations
N/AReaders
Get full text

Heart Disease and Stroke Statistics-2019 Update: A Report From the American Heart Association

6972Citations
N/AReaders
Get full text

Prevention of Stroke by Antihypertensive Drug Treatment in Older Persons With Isolated Systolic Hypertension: Final Results of the Systolic Hypertension in the Elderly Program (SHEP)

0
4746Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Thiazide and the Thiazide-Like Diuretics: Review of Hydrochlorothiazide, Chlorthalidone, and Indapamide

46Citations
N/AReaders
Get full text

Use of Hydrochlorothiazide and Risk of Melanoma and Nonmelanoma Skin Cancer

38Citations
N/AReaders
Get full text

Treatment and prescribing trends of antihypertensive drugs in 2.7 million UK primary care patients over 31 years: a population-based cohort study

25Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

McNally, R. J., Morselli, F., Farukh, B., Chowienczyk, P. J., & Faconti, L. (2019, December 1). A review of the prescribing trend of thiazide-type and thiazide-like diuretics in hypertension: A UK perspective. British Journal of Clinical Pharmacology. Blackwell Publishing Ltd. https://doi.org/10.1111/bcp.14109

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 12

67%

Lecturer / Post doc 3

17%

Researcher 3

17%

Readers' Discipline

Tooltip

Pharmacology, Toxicology and Pharmaceut... 10

48%

Medicine and Dentistry 8

38%

Business, Management and Accounting 2

10%

Materials Science 1

5%

Save time finding and organizing research with Mendeley

Sign up for free