Feasibility and Efficacy of Microwave Ablation Combined with Iodine-125 Seed Implantation in Local Control of Recurrent Retroperitoneal Liposarcomas: Initial Clinical Experience

Abstract

Introduction. The objective of the present study was to evaluate the feasibility, safety, and short-term efficacy of microwave ablation (MWA) combined with iodine-125 (I-125) seed implantation in recurrent retroperitoneal liposarcomas (rRPLs).Materials and Methods. From September 2012 to March 2015, 11 patients were enrolled in this prospective study. Eleven tumors (median, 9 cm; range, 5.5-12.5 cm) were treated with computerized tomography-guided MWA for 11 sessions and I-125 seed implantation for 18 sessions. I-125 seed implantation was performed 4 weeks after MWA.Results. There were no procedure-related deaths. Post-MWA pain (grade >= 2) was the most common complication (6 of 11 patients, 54.5%), and fever (grade >= 2) was observed in two patients. Reversible nerve injury, defined as transient limb paresthesia or leg weakness, was observed in one patient. There were fewer complications associated with the I-125 seed implantation procedure compared with the MWA procedure. All 11 patients who underwent the MWA procedure achieved a partial response (PR), according to the modified Response Evaluation Criteria in Solid Tumors, 1 month post-ablation; after I-125 seed implantation was performed, a complete response was observed in three, five, and six target tumors in 3, 6, and 12 months, respectively.Conclusion. In selected patients with rRPLs, MWA combined with I-125 seed implantation is feasible and safe with favorable local control efficacy. PU - WILEY PI - HOBOKEN PA - 111 RIVER ST, HOBOKEN 07030-5774, NJ USA