Therapeutic exercise accompanied by neuronal modulation to enhance neurotrophic factors in the brain with central nervous system disorders

Abstract

Exercise is a primary therapeutic regimen in physical therapy to rehabilitate the motor function of patients with central nervous system (CNS) disorders such as cerebrovascular accident (CVA). Furthermore, exercise positively contributes to cognitive function related to neuroplasticity and neuroprotection in the hippocampus. Neurotrophins play a crucial role in neuroplasticity, neurogenesis, and neuroprotection in the CNS. Exercise enhances the expression of neurotrophins in the brain. Thus, novel regimens for kinesiotherapy in CNS disorders to further enhance exercise-induced expression are expected. In this review, we described three novel regimens for kinesiotherapy in CNS disorders based on the interaction between exercise and pharmacological treatment with the idea of "inhibition of inhibition" in the CNS.