Synthesis, characterization and cytotoxic activity of new indole schiff bases, derived from 2-(5-chloro-3,3-dimethyl-1,3-dihydro-indol-2-ylidene)-malonaldehyde with substituted aniline

Abstract

Series of new compounds of indole Schiff base derivatives have been synthesized by reaction of 2-(5-Chloro-3,3-dimethyl-1,3-dihydro-indol-2-ylidene)-malonaldehyde with aniline substituted. The chemical structures of the synthesized compounds were characterized by TLC, FT-IR, 1H, 13C NMR and APT 13C NMR. The in vitro anticancer activity of the new synthesized compounds tested against-AMJ breast cancer cell line. The revealed data showed that compounds have promising anticancer activity against AMJ13 cell line at low concentrations.