The central inflammatory regulator IκBζ: induction, regulation and physiological functions

19Citations
Citations of this article
25Readers
Mendeley users who have this article in their library.

Abstract

IκBζ (encoded by NFKBIZ) is the most recently identified IkappaB family protein. As an atypical member of the IkappaB protein family, NFKBIZ has been the focus of recent studies because of its role in inflammation. Specifically, it is a key gene in the regulation of a variety of inflammatory factors in the NF-KB pathway, thereby affecting the progression of related diseases. In recent years, investigations into NFKBIZ have led to greater understanding of this gene. In this review, we summarize the induction of NFKBIZ and then elucidate its transcription, translation, molecular mechanism and physiological function. Finally, the roles played by NFKBIZ in psoriasis, cancer, kidney injury, autoimmune diseases and other diseases are described. NFKBIZ functions are universal and bidirectional, and therefore, this gene may exert a great influence on the regulation of inflammation and inflammation-related diseases.

Cite

CITATION STYLE

APA

Feng, Y., Chen, Z., Xu, Y., Han, Y., Jia, X., Wang, Z., … Lv, W. (2023). The central inflammatory regulator IκBζ: induction, regulation and physiological functions. Frontiers in Immunology. Frontiers Media SA. https://doi.org/10.3389/fimmu.2023.1188253

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free