Comparison of adjunctive naoxintong versus clopidogrel in volunteers with the CYP2C19 * 2 gene mutation accompanied with qi deficiency and blood stasis constitution

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Abstract

This study was to determine the impact of adjunctive Buchang Naoxintong Jiaonang (BNJ) to clopidogrel on volunteers with the CYP2C19*2 gene mutation accompanied with qi deficiency and blood stasis (QDBS) constitution. Eighteen males with QDBS constitution were selected, who were 6 CYP2C19*1/*1, 6 CYP2C19*1/*2, and 6 CYP2C19*2/ *2, and signed informed consent. Results showed that the maximal platelet aggregation (Aggmax) and 5min aggregation (Agglate) with 5-mol/L ADP in three different CYP2C19*2 genotypes were significantly decreased after any drug therapy compared with corresponding baseline measurements (all values P <.05). But percent inhibitions of Aggmax and Agglate (IPAs) in CYP2C19*2/*2 genotype at 4 hours, 24 hours, 3 days, and 7 days after clopidogrel administration were all the lowest among three CYP2C19*2 genotypes (P <.01), and IPAs in CYP2C19*1/*2 genotype were between CYP2C19*1/*1 and CYP2C19*2/*2. IPAs had no significant difference among three different CYP2C19*2 genotypes after BNJ or adjunctive BNJ. In addition, changes of CD62P, PAC1, and sCD40L were similar to changes of ADP-induced platelet aggregation in three different CYP2C19*2 genotypes. Conclusion was that adjunctive BNJ to clopidogrel can enhance the antiplatelet effect in volunteers with the CYP2C19*2 gene mutation. Copyright © 2011 Hui Chen et al.

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APA

Chen, H., Yu, G., Sun, H., Wu, X., & Wang, H. (2011). Comparison of adjunctive naoxintong versus clopidogrel in volunteers with the CYP2C19 * 2 gene mutation accompanied with qi deficiency and blood stasis constitution. Evidence-Based Complementary and Alternative Medicine. https://doi.org/10.1155/2011/207034

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