Comparison of adjunctive naoxintong versus clopidogrel in volunteers with the CYP2C19 * 2 gene mutation accompanied with qi deficiency and blood stasis constitution

Abstract

This study was to determine the impact of adjunctive Buchang Naoxintong Jiaonang (BNJ) to clopidogrel on volunteers with the CYP2C19*2 gene mutation accompanied with qi deficiency and blood stasis (QDBS) constitution. Eighteen males with QDBS constitution were selected, who were 6 CYP2C19*1/*1, 6 CYP2C19*1/*2, and 6 CYP2C19*2/ *2, and signed informed consent. Results showed that the maximal platelet aggregation (Aggmax) and 5min aggregation (Agglate) with 5-mol/L ADP in three different CYP2C19*2 genotypes were significantly decreased after any drug therapy compared with corresponding baseline measurements (all values P