Organocatalytic α-Aminoalkylation of Azomethine Imines by α-Silylamines under Blue LED Light

Abstract

A synthetic method to prepare 1,2-diamines efficiently that relies on the 4CzPN-catalysed α-aminoalkylation of azomethine imines by secondary and tertiary α-silylamines under blue light emitting diode (LED) light (456 nm) is described. Achieved under metal- and additive-free reaction conditions at room temperature, the synthetic protocol was shown to afford product yields up to 99% and applicable to the late-stage functionalisation of three drug molecules and the gramme-scale preparation of one example.