Abstract
Two new anti-aging compounds, ganodermasides C and D, were isolated and their structures elucidated. They are novel ergosterols possessing a 4,6,8(14),22-tetraene-3-one unit with unique hydroxylation at C-9. Both of them significantly extended the replicative lifespan of the K6001 yeast strain. Ganodermasides C and D regulated the expression of the gene for UTH1 to prolong the replicative lifespan of yeast.
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Weng, Y., Lu, J., Xiang, L., Matsuura, A., Zhang, Y., Huang, Q., & Qi, J. (2011). Ganodermasides C and D, two new anti-aging ergosterols from spores of the medicinal mushroom Ganoderma lucidum. Bioscience, Biotechnology and Biochemistry, 75(4), 800–803. https://doi.org/10.1271/bbb.100918
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