Recent approaches in the synthesis of conformationally restricted nucleoside analogues

Abstract

This review describes some approaches in the synthesis of conformationally restricted nucleoside analogues. The focus is on the preparation of nucleosides as monomers modified only on the pentofurano sugar moiety, with an additional linkage capable of modulating the dynamic conformational equilibrium of natural nucleosides. The results of the different structural modifications in terms of pseudorotational analysis, as well as the potential use of such conformationally restricted nucleoside analogues, are briefly presented. © Wiley-VCH Verlag GmbH & Co. KGaA, 2008.