The synthesis and the odor tonalities of racemic 5-demethyl-α-ionone are described. This synthetic ionone derivative did not show the typical floral-woody violet smell of α-ionone, definitely proving the importance of a suitably sized and spatially oriented alkyl substituent at C(5) for stimulating olfactory receptors of ionones.
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CITATION STYLE
Chierici, S., Bugoni, S., Porta, A., Zanoni, G., & Vidari, G. (2015). The importance of the 5-alkyl substituent for the violet smell of ionones: Synthesis of racemic 5-demethyl-α-ionone. Natural Product Communications, 10(6), 847–852. https://doi.org/10.1177/1934578x1501000612