Toxicity evaluation of silver nanoparticles synthesized by chemical and green route in different experimental models

Abstract

With the increased exposure of silver nanoparticles (AgNPs) to human beings, the risk and safety should be considered. In this study, nephro-toxicity of AgNPs prepared by chemical and green route (aqueous extract of Desmodium gangeticum root) in rat, proximal epithelial cell lines and renal mitochondria was evaluated. AgNPs (100 mg/kg) were administered orally to the wistar rats. After 15 d, we observed significant changes in the renal architecture of both AgNPs, supported by the urine and blood chemistry data. Further, exposure towards renal epithelial cells and renal mitochondria also confirm the toxic similarities between the AgNPs synthesized from two routes.