Association study of a serotonin receptor 2A gene - 1438A/G polymorphism and anxiety-related traits

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Abstract

Objective: The aim of this study was to investigate the relationship between the -1438 A/G polymorphism of serotonin receptor 2A (5HTR2A) and anxiety-related traits in Korean adolescent females. Methods: A total of 174 Korean adolescent females were tested for the - 1438A/G polymorphism of 5HTR2A using polymerase chain reaction (PCR)-based methods. Anxiety-related traits were evaluated using the Anxiety Sensitivity Index (ASI) and the trait form of the Spielberg State-Trait Anxiety Inventory (T-STAI). Results: There was no difference between the genotypes with respect to scores pertaining to anxiety-related traits. Although the G allele carriers (GG or AG genotype) scored lower on the psychological subscale of the ASI (4.76±3.00 vs 5.98±4.00, p=0.038), this difference was not significant after Bonferroni correction. Conclusion: These findings suggest that the - 1438A/G polymorphism of 5HTR2A might not be associated with anxiety sensitivity or trait anxiety. Copyright © 2008 Official Journal of Korean Neuropsychiatric Association.

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Kim, K. H., Woo, H. Y., & Lim, S. W. (2008). Association study of a serotonin receptor 2A gene - 1438A/G polymorphism and anxiety-related traits. Psychiatry Investigation, 5(4), 244–246. https://doi.org/10.4306/pi.2008.5.4.244

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