Association study of a serotonin receptor 2A gene - 1438A/G polymorphism and anxiety-related traits

5Citations
Citations of this article
22Readers
Mendeley users who have this article in their library.

Abstract

Objective: The aim of this study was to investigate the relationship between the -1438 A/G polymorphism of serotonin receptor 2A (5HTR2A) and anxiety-related traits in Korean adolescent females. Methods: A total of 174 Korean adolescent females were tested for the - 1438A/G polymorphism of 5HTR2A using polymerase chain reaction (PCR)-based methods. Anxiety-related traits were evaluated using the Anxiety Sensitivity Index (ASI) and the trait form of the Spielberg State-Trait Anxiety Inventory (T-STAI). Results: There was no difference between the genotypes with respect to scores pertaining to anxiety-related traits. Although the G allele carriers (GG or AG genotype) scored lower on the psychological subscale of the ASI (4.76±3.00 vs 5.98±4.00, p=0.038), this difference was not significant after Bonferroni correction. Conclusion: These findings suggest that the - 1438A/G polymorphism of 5HTR2A might not be associated with anxiety sensitivity or trait anxiety. Copyright © 2008 Official Journal of Korean Neuropsychiatric Association.

Cite

CITATION STYLE

APA

Kim, K. H., Woo, H. Y., & Lim, S. W. (2008). Association study of a serotonin receptor 2A gene - 1438A/G polymorphism and anxiety-related traits. Psychiatry Investigation, 5(4), 244–246. https://doi.org/10.4306/pi.2008.5.4.244

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free