A framework for understanding the evasion of host immunity by Candida biofilms

Citations of this article
Mendeley users who have this article in their library.


Candida biofilms are a major cause of nosocomial morbidity and mortality. The mechanism by which Candida biofilms evade the immune system remains unknown. In this perspective, we develop a theoretical framework of the three, not mutually exclusive, models, which could explain biofilm evasion of host immunity. First, biofilms may exhibit properties of immunological silence, preventing immune activation. Second, biofilms may produce immune-deviating factors, converting effective immunity into ineffective immunity. Third, biofilms may resist host immunity, which would otherwise be effective. Using a murine subcutaneous biofilm model, we found that mice infected with biofilms developed sterilizing immunity effective when challenged with yeast form Candida. Despite the induction of effective anti-Candida immunity, no spontaneous clearance of the biofilm was observed. These results support the immune resistance model of biofilm immune evasion and demonstrate an asymmetric relationship between the host and biofilms, with biofilms eliciting effective immune responses yet being resistant to immunological clearance.




Garcia-Perez, J. E., Mathé, L., Humblet-Baron, S., Braem, A., Lagrou, K., Van Dijck, P., & Liston, A. (2018, March 16). A framework for understanding the evasion of host immunity by Candida biofilms. Frontiers in Immunology. Frontiers Media S.A. https://doi.org/10.3389/fimmu.2018.00538

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free