Intrathecal substance P elicits a caudally-directed biting and scratching behavior in mice

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Abstract

Intrathecal injection of substance P in mice elicited a dose-related biting and scratching response. Systemic but not intrathecal morphine sulfate antagonized this response. We interpret these observations to define a novel nociceptive response to intrathecal substance P. © 1981.

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Hylden, J. L. K., & Wilcox, G. L. (1981). Intrathecal substance P elicits a caudally-directed biting and scratching behavior in mice. Brain Research, 217(1), 212–215. https://doi.org/10.1016/0006-8993(81)90203-1

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