Cooperative study of intracranial aneurysms and subarachnoid hemorrhage. Report on a randomized treatment study II. Objectives and design of randomized aneurysm study

Abstract

Four selected treatmenls. namely, regulated bed rest, drug-induced hypotension, carotid ligation. and ini rueranial surgery, were randomly allocated with respect to location of the aneurysm und interval following last bleed. The objective of the Study was to answer the question. “What mode of treatment offers a patient with a single ruptured intracranial aneurysm during the previous three months the highest probability of optimal results with respect to sur vival, residual neurological deficit, capacity for self-care, and gainful employment?” Variou treatments were suspended at specific intervals when a particular mode of therapy became in ferior to the others. A group of 33 patients was disqualified after treatment was randomly allocated. Th numbers of protocols remaining for analysis within each treatment category were 202 fc regulated had rest. 309 for drug-induced hypotension, 187 for carotid ligation, and 274 for irtracranial surgery. © 1974 American Heart Association, Inc.