Mannose-functionalized mesoporous silica nanoparticles for efficient two-photon photodynamic therapy of solid tumors

Abstract

Zap 'em! Multifunctionalized mesoporous silica nanoparticles induce significant reduction of tumor size upon two-photon excitation in the near-infrared region while being nontoxic under daylight illumination. These nanoparticles were further tested for in vivo two-photon photodynamic therapy (TPE-PDT). A 70 % regression of tumor size after a single treatment was observed in athymic mice bearing tumor xenografts. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.