C-glycosyl flavonoids-rich extract of Dipcadi erythraeum Webb & Berthel. Bulbs: Phytochemical and anticancer evaluations

Abstract

Dipcadi erythraeum Webb & Berthel. is a wild edible species belonging to family Asparagaceae and commonly used in folk medicine. The D. erythraeum bulbs extract was subjected to chemical investigation using Liquid Chromatography-Electrospray Ionization Mass Spectrometry (LC-ESI-MS) technique to identify its polar active constituents and evaluated against four human carcinoma cell lines; MCF7, HEPG2, A549, and HCT116. The D. erythraeum bulbs extract revealed 22 phenolic compounds characterized for the first time from the studied species, 14 of them were identified as C-glycosyl flavonoids. Moreover, the studied extract showed moderate activity against MCF7 and HCT116 at 100 μg/ml with cell viability of 43.6% and 48.4%, respectively. From the chemotaxonomic point of view, the presence of C-glycosyl flavonoids supported that D. erythraeum has a closer relationship with the species of Asparagaceae family than Liliaceae.