Drug interactions

Abstract

Adverse drug interaction it is therapeutically unwanted effect, which may appear during simultaneous treatment with two or more drugs and as a consequence may reduce or increase their pharmacologic action; may lead to the toxic effects and even to the appearance of qualitatively different from the expected one pharmacologic action. In this article are presented criteria determining the clinical significance, risk factors, kinds and consequences of adverse drug interactions. The drugs which can be the most dangerous in the context of adverse interactions, when are used simultaneously with other medications are: anaesthetics, anticoagulants, antidiabetics, nonsteroidal antiinflammatory drugs, drugs used in cardiac and circulatory system diseases, hypolipaemic drugs, theophylline, antibiotics, psychotropics, antiepileptics, antineoplastics, cyclosporine, tacrolimus.