Therapeutic targeting of IL-7Rα signaling pathways in ALL treatment

Abstract

Increased understanding of pediatric acute lymphoblastic leukemia (ALL) pathobiology has led to dramatic improvements in patient survival. However, there is still a need to develop targeted therapiesto enable reduced chemotherapy intensity and to treat relapsed patients. The interleukin-7 receptor a (IL-7Ra) signaling pathways are prime therapeutic targets because these pathways harbor genetic aberrations in both T-cell ALL and B-cell precursor ALL. Therapeutic targeting of the IL-7Ra signaling pathways may lead to improved outcomes in a subset of patients.