A new antimycobacterial furanolignan from Leucophyllum frutescens

Abstract

Bioassay-guided fractionation of the minor active fractions obtained from the root bark of Leucophyllum frutescens (Berl.) I. M. Johnst. led to isolation from the n-hexane extract of a new compound with moderate activity against the H37Rv Mycobacterium tuberculosis strain (MIC 63 μg/mL), and low cytotoxicity, as shown by the IC50 against Vero cells. The compound was identified by 1D/2D NMR spectroscopy as 2′,5″-dimethoxysesamin.