Hypercoagulability, intravascular thrombosis, and thrombocytosis associated with COVID-19. Case report

Abstract

A new pandemic in the 21st century, generated by a coronavirus-like viral agent called SARS CoV-2, which produces the disease COVID-19, the same that debuted in late 2019 in China, with significant mortality, affecting the lower respiratory tract and It manifests as pneumonia in humans. As its worldwide expansion, the virus has presented mutations and therefore phenotypic variants that have generated clinical pictures that are far from the symptoms described initially; rather, coagulation disturbances and intense inflammation (cytokine storm) have created atypical symptoms and different therapeutic approaches; placing ferritin and D-dimer as cardinal biomarkers to decide anticoagulation and anti-inflammatory therapy such as corticotherapy, monoclonal anti IL6 Tocilizumab or methotrexate, among others. Below we present the case of a patient diagnosed with COVID-19 with RT-PCR, who shows more than his respiratory manifestations. This prothrombotic state triggered intravascular thrombosis and possibly pulmonary embolism, with elevated values of ferritin and D-dimer, which after anticoagulation and administration of corticosteroids exceeded his state of extreme gravity and discharged from Intensive Care.