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New players in heterochromatin silencing: Histone variant H3.3 and the ATRX/DAXX chaperone

Nucleic Acids Research
DOI: 10.1093/nar/gkw012
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Abstract

A number of studies have demonstrated that various components of the ATRX/DAXX/Histone H3.3 complex are important for heterochromatin silencing at multiple genomic regions. We provide an overview of the individual components (ATRX, DAXX and/or H3.3) tested in each study and propose a model where the ATRX/DAXX chaperone complex deposits H3.3 to maintain the H3K9me3 modification at heterochromatin throughout the genome.

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Voon, H. P. J., & Wong, L. H. (2015, December 31). New players in heterochromatin silencing: Histone variant H3.3 and the ATRX/DAXX chaperone. Nucleic Acids Research. Oxford University Press. https://doi.org/10.1093/nar/gkw012

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