FLAVONOIDS FROM RHYNCHOSIA PSEUDO-CAJAN AS SUITABLE α-GLUCOSIDASE INHIBITORS AND FREE RADICAL SCAVENGERS

Abstract

A series of nine flavonoids, 1-9, isolated from Rhynchosia pseudo-cajan Cambess., has been investigated in present work for their biological potential against alpha-glucosidase, lipoxygenase (LOX), acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes; and antioxidant activity against diphenylpicrylhydrazyl (DPPH) radical respectively. The results revealed that these flavonoids are very suitable inhibitors of a-glucosidase and moderate ones of AChE enzyme. Against BChE enzyme, only myricetin (7) while against LOX, quercetin (6) and myricetin (7) remained active as shown by their IC50 values. Moderate to excellent scavenging activity was also depicted by these molecules against DPPH. The modes of interaction of some active compounds against a-glucosidase and BChE were computationally observed and correlated with the experimental results.