Automated multistep synthesis of 2-pyrazolines in continuous flow

Abstract

The rapid multistep synthesis of 2-pyrazolines from aldehydes via [3 + 2] cycloaddition of unstabilised diazo species and mono and di-substituted alkenes is reported. The development encompasses semi-continuous and fully continuous methods, including a fully automated compound library generation. A graphical interface was developed for the automation control, making it more accessible for chemists without coding experience.