A simulation model for interaction between cyclic variation of brain tissue temperature and intracranial pressure

Abstract

The brain responds with high sensitivity in case of cerebral damage. Brain temperature (BT), cerebral blood flow (CBF), cerebral blood volume (CBV) and intracranial pressure (ICP) are essential parameters for brain revival in case of cerebral damage. For this reason, the coordinated learning of BT, CBF and ICP is required for improving the remedial impacts. Thus, in this exploration, a simulation model has been developed for association between brain tissue temperature (BTT), CBF, CBV and ICP to improve the apprehensions of the ICP. It includes the cardiac output, partial pressures of oxygen and carbon dioxide in cerebral artery and vein, temperature variations of brain tissue, cerebral metabolic process and pressure-volume relationship for cranial cavity. The model simulates the interaction between arterial blood pressure, BTT, produced amount of CO2 from brain tissue, changes in CBV and changes in ICP. The results show that the ICP and CBV will increase with an increase in brain tissue temperature. This model elaborates the physiology of BTT and ICP with less complexity.