Association of human leukocyte antigen class II alleles with severe Middle East respiratory syndrome-coronavirus infection

Abstract

BACKGROUND: Middle East Respiratory Syndrome (MERS) is a disease of the lower respiratory tract and is characterized by high mortality. It is caused by a beta coronavirus (CoV) referred to as MERS-CoV. Majority of MERS-CoV cases have been reported from Saudi Arabia. AIM: We investigated the human leukocyte antigen (HLA) Class II alleles in patients with severe MERS who were admitted in our Intensive Care Unit. METHODS: A total of 23 Saudi patients with severe MERS-CoV infection were typed for HLA class II, results were compared with those of 161 healthy controls. RESULTS: Two HLA class II alleles were associated with the disease; HLA-DRB1∗11:01 and DQB1∗02:02, but not with the disease outcome. CONCLUSIONS: Our results suggest that the HLA-DRB1∗11:01 and DQB1∗02:02 may be associated with susceptibility to MERS.