Immunomodulatory effects of excretory/ secretory compounds from Contracaecum osculatum larvae in a zebrafish inflammation model

20Citations
Citations of this article
32Readers
Mendeley users who have this article in their library.

Abstract

Excretory/secretory (ES) compounds isolated from third-stage larvae of the anisakid nematode Contracaecum osculatum parasitizing liver of Baltic cod were investigated for effects on immune gene expression in a zebrafish LPS-induced inflammation model. ES products containing a series of proteins, of which some had enzymatic activity, were injected solely or with LPS. ES proteins alone induced up-regulation of a number of immune-related genes, but generally to a lower degree compared to LPS. When co-injected with LPS, the worm products exacerbated merely expression of five genes affecting Th1, Th2, Th17 and innate responses compared to the LPS-injected group. However, the level of overexpression decreased in an inverse dose-dependent manner. The immune regulating action of C. osculatum ES products is interpreted as an important evolutionary ability of larval parasites in the transport host which makes it less susceptible to host immune responses whereby the probability of reaching the final host is increased.

Cite

CITATION STYLE

APA

Mehrdana, F., Kania, P. W., Nazemi, S., & Buchmann, K. (2017). Immunomodulatory effects of excretory/ secretory compounds from Contracaecum osculatum larvae in a zebrafish inflammation model. PLoS ONE, 12(7). https://doi.org/10.1371/journal.pone.0181277

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free