Studies on Metabolites of Mycoparasitic Fungi. III. New Sesquiterpene Alcohol from Trichoderma koningii

Abstract

A new sesquiterpene alcohol, named tricho-acorenol (1), was isolated from the culture broth of Trichoderma koningii oudemans along with methyl benzoate (2), cyclonerodiol (3), cyclo-(L-Pro-L-Leu) (4), 4-hydroxyphenethyl alcohol (5), uracil (7), and a ceramide (6). The ceramide (6) was identified as (2S,3S,4R)-2-[(2R)-2-hydroxytetracosanoylamino]-l,3,4-octadecanetriol by the use of ion-spray ionization MS (ISI-MS) and comparison of the optical rotation and the 1H-NMR data with those of (2S,3S,4R)-2-[(2R)-2-hydroxytetracosanoylamino]-1,3,4-hexadecanetriol. The structure of tricho-acorenol was elucidated to be (1S,4S,5S,7R)-l-isopropyl-4,8-dimethyl-spiro-f4.51dec-8-en-7-ol on the basis of chemical and spectroscopic evidence. © 1995, The Pharmaceutical Society of Japan. All rights reserved.