A multicomponent reaction for the one-pot synthesis of 4-aza-2,3-didehydropodophyllotoxin and derivatives

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Abstract

equation presented A convergent method has been found to prepare 4-aza-2,3-didehydropodophyllotoxin and derivatives in a one-pot procedure. The mechanism of the reaction between tetronic acid, anilines, and benzaldehydes is discussed.

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Tratrat, C., Giorgi-Renault, S., & Husson, H. P. (2002). A multicomponent reaction for the one-pot synthesis of 4-aza-2,3-didehydropodophyllotoxin and derivatives. Organic Letters, 4(19), 3187–3189. https://doi.org/10.1021/ol0200908

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