Abstract
Triacsins A and B, new inhibitors of acyl-CoA synthetase, were isolated from the cultured broth of Streptomyces sp. strain SK-1894. The structurally related compounds WS-1228 A and B, known as hypotensive vasodilators, were also found to inhibit acyl-CoA synthetase. The four compounds have in common a N-hydroxytriazene moiety in their structures. The IC50values for triacsin A and WS-1228 A were 5.5 and 3.6 μg/ml, respectively. © 1986, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.
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CITATION STYLE
Ōmura, S., Tomoda, H., Xu, Q. M., Takahashi, Y., & Iwai, Y. (1986). Triacsins, new inhibitors of acyl-coa synthetase produced by streptomyces SP. The Journal of Antibiotics, 39(9), 1211–1218. https://doi.org/10.7164/antibiotics.39.1211
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