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Application of whole-genome sequencing to an unusual outbreak of invasive group a streptococcal disease

Open Forum Infectious Diseases (2016) 3(1)
DOI: 10.1093/ofid/ofw042
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Abstract

Whole-genome analysis was applied to investigate atypical point-source transmission of 2 invasive group A streptococcal (GAS) infections. Isolates were serotype M4, ST39, and genetically indistinguishable. Comparison with MGAS10750 revealed nonsynonymous polymorphisms in ropB and increased speB transcription. This study demonstrates the usefulness of whole-genome analyses for GAS outbreaks.

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Galloway-Peña, J., Clement, M. E., Kuinkel, B. K. S., Ruffin, F., Flores, A. R., Levinson, H., … Fowler, V. G. (2016). Application of whole-genome sequencing to an unusual outbreak of invasive group a streptococcal disease. Open Forum Infectious Diseases, 3(1). https://doi.org/10.1093/ofid/ofw042

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