Chemoselective reduction of carbonyl groups of aromatic nitro carbonyl compounds to the corresponding nitroalcohols using thiourea dioxide

Abstract

Aromatic nitroaldehydes and ketones were selectively reduced to the corresponding nitroalcohols by thiourea dioxide (TUDO) in aqueous alkali-ethanolic system in good to high yields. The optimized synthetic methodology is simple, convenient and highly chemoselective.