A novel basal body protein that is a polo-like kinase substrate is required for basal body segregation and flagellum adhesion in trypanosoma brucei

Abstract

Background: The substrates of Polo-like kinase in Trypanosoma brucei are mostly not identified. Results: A basal body protein was identified as a substrate of Polo-like kinase and is required for basal body segregation and flagellum adhesion. Conclusion: Polo-like kinase regulates a basal body protein. Significance: Dissecting the Polo-like kinase pathway is crucial for understanding its cellular functions.