Design, Synthesis, In Silico Study and Anti-Inflammatory Evaluation of New Ketoprofen Thiourea Derivatives

Abstract

The In the current study, six new derivatives of ketoprofen thiourea were designed and synthesized In order to enhance COX-2 enzyme selectivity. The chemical structures of these derivatives were confirmed by spectral analysis. The anti-inflammatory activities of these derivatives was investigated insilico and in vivo. The results revealed that compound B4 were the most active.  The new derivatives also showed drug-likeness and gastric absorption as predicted by computational methods.  These results above indicated that the synthesized compounds deserve additional investigation as potential selective COX-2 inhibitors.