PPARδ is a type 1 IFN target gene and inhibits apoptosis in T cells

Abstract

Peroxisome proliferator-activated receptor β/δ (PPARδ) is a nuclear hormone receptor regulating diverse biological processes, including β-oxidation of fatty acid and epithelial cell differentiation. To date, the role of PPARδ in the immune system has not been thoroughly studied. Here, we show that PPARδ is expressed in activated human T cells purified from peripheral blood as well as in T cells isolated from affected psoriasis skin lesions. PPARδ is induced in T cells on stimulation with type 1 IFN. Functionally, PPARδ enhances proliferation of primary T cells and blocks apoptosis induced by type 1 IFN and by serum deprivation. We show that these cellular functions are mediated by the activation of extracellular signal-regulated kinase1/2 signaling. Our results (1) establish a direct molecular link between type 1 IFN signaling and PPARδ, (2) define a functional role for PPARδ in human T cells, and (3) suggest that the induction of PPARδ by type 1 IFN contributes to the persistence of activated T cells in psoriasis skin lesions. © 2008 The Society for Investigative Dermatology.