Clinical effects of Vitamin D in patients affected with Osteoporosis in the city of Tikrit

Abstract

Background: Osteoporosis that is characterized by low bone mass and strength which in turn increases the risk of developing fractures. It is sometimes referred to as silent disease due to its asymptomatic obsolescence until first fracture occurs. Current study was conducted to study the effect of vitamin D using a clinical dose of this vitamin given twice a day to osteoporosis patients in the city of Tikrit and from both sexes who visit Dr. Abdulrazzaq Mahmood Al-Khattabi's clinic and Salahuddin General Hospital. Methods: The research involved 86 subjects (26 males and 60 females) aged between (25-79) years to study the clinical effect of vitamin D on them. In addition, 36 subjects (20 males and 16 females) aged between (25-79 years) of healthy persons were recruited as a control group. The research subjects were divided into two groups; the first of which included the age group (25-54) years while the second included the age group (65-79) years. They were each given a dose of (5000IU) of vitamin D and a dose of (500mg) of calcium twice a day, in the morning and in the evening, for three months with follow-up of subjects periodically each month to observe the changes by measuring a number of biochemical parameters represented in the examination of bone density, vitamin D, serum calcium, serum alkaline phosphatase and C-Reactive Protein. Patients with rheumatism, taking cortisone or any item containing it, and pregnant women were excluded from this research. Results: The results shown a significant increase in bone density in both groups and for both sexes as well as higher levels of vitamin D and calcium compared to the control group. However, the results showed a significant decrease in alkaline phosphatase effectiveness in both groups. Moreover, there was a decrease in the level of C-Reactive Protein in males of both groups and in females from the first group. No significant differences were recorded in the second group compared to the control group.