A review of the potential for bacteriophages to effect antibiofilm activity, using selected examples

Abstract

It has been over a hundred years since the original publications on bacteriophages were first presented. In the following century, the world of microbiology has moved on significantly. In 2015, ∼100 years later, the UK Government and the Wellcome Trust published a report on the current state of antimicrobial resistance, with guidance for the future. The pressing need for new antibiotics, or alternatives to them, is one of the fundamental drivers of research in to the application of bacteriophages to treat incidents of infectious disease. This review will look at research published on the use of bacteriophages, with a specific focus on their use against bacterial biofilms.