A potent cytotoxic metabolite from terrestrial actinomycete, Streptomyces collinus

Abstract

In the present study a cytotoxic secondary metabolite, 4-hydroxy-4-(4- nitrophenyl)butan-2-one (compound-1), was isolated from the fermentation broth of the terrestrial actinomycetes. The strain was collected from high altitude regions of Kashmir and it was confirmed as Streptomyces collinus (SRP-19) on the basis of 16S rDNA analysis. To the best of our knowledge the compound-1 has not been reported so far from natural sources. The structure of the isolated compound was established by means of spectroscopic analysis including 1H, 13C, 2D NMR and it was also evaluated for its cytotoxic potential against four cancer cell lines, viz., HeLa, PC-3, THP and Caco-2 cells. Compound 1 exhibited significant cytotoxic activity, having IC50 values within a range of 5.39-8.86 μM. © 2013 Springer Science+Business Media New York.