Evaluation of haematological and reproductive effect of paracetamol (Acetaminophen) in female abino rats

Abstract

The effect of oral administration of 7. 5 mg/kg BW on haematological and plasma biochemical parameters in albino rats were investigated. The paracetamol was administered by gavage on daily basis for haematological study; the paracetamol was administered orally for 21 days for estrous cycle study. Treatment of rats with 7. 5 mg/kg BW of paracetamol caused insignificant (p>0. 05) changes in the RBC, PCV, HBTWBC, platelet, neutrophil, lymphocyte, eosinophil, monocyte and haematmetric indices (MCV, MCHC, MCH) values relative to their respective controls. Treatment of rats with paracetamol (7. 5 mg/kg BW) caused non-significant changes in the duration of all phases of estrous cycle relative to their relative to their respective controls. These findings probably indicates that paracetamol has no deleterious effect on the blood chemistry and fertility of female albino rats.