Active tumor-targeting luminescent gold clusters with efficient urinary excretion

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Abstract

We present novel active targeting luminescent gold nanoclusters (AuNCs), which are prepared through a one-pot procedure by using a pentapeptide (CRGDS) for stabilization and tumor recognition. CRGDS-AuNCs exhibit a high tumor-specific retention with an exceptionally high tumor-to-liver uptake ratio of 9.3. Their small hydrodynamic diameter and zwitterionic surface facilitate urinary excretion, which reaches 82% within 24 h after injection.

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Wang, X., He, H., Wang, Y., Wang, J., Sun, X., Xu, H., … Huang, F. (2016). Active tumor-targeting luminescent gold clusters with efficient urinary excretion. Chemical Communications, 52(59), 9232–9235. https://doi.org/10.1039/c6cc03814j

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