Futalosine and its derivatives, new nucleoside analogs

Abstract

Futalosine, a new nucleoside analog, was isolated from a fermentation broth of Streptomyces sp. MK359-NF1. Some chemical derivatives of futalosine were prepared. 6-O-Methylfutalosine methylester inhibited growth of HeLa-S3 cells in vitro (IC50=19.5μg/ml) in contrast to the weak activity of futalosine. 6-O-Methylfutalosine methylester at concentrations higher than 10 μg/ml inhibited incorporation of 3H-TdR and 3H-UR but not 3H-Leu into the acid-soluble fractions of HeLa-S3 cells.