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Boosting antibody-dependant cellular cytotoxicity against tumor cells with a CD137 stimulatory antibody

OncoImmunology (2012) 1(6) 957-958
DOI: 10.4161/onci.19974
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Abstract

Monoclonal antibodies (mAb) induce tumor regression through antibody-dependant cellular cytotoxicity (ADCC). we recently showed that an agonistic anti-CD137 mAb stimulates natural killer (NK) cells which have been activated by a tumor-specifc mAb, resulting in increased ADCC against cancer cells. © 2012 Landes Bioscience.

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Houot, R., Kohrt, H., & Levy, R. (2012). Boosting antibody-dependant cellular cytotoxicity against tumor cells with a CD137 stimulatory antibody. OncoImmunology, 1(6), 957–958. https://doi.org/10.4161/onci.19974

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