Screening of MicroRNA as potential CardiomiRs in Rattus noveregicus Heart related Dataset

Abstract

MicroRNAs (miRNAs) are the naturally expressed small, 18~25 nts long non-coding single stranded RNAs, which inhibit the translation by interacting with the 3' untranslated region (UTR) of specific mRNA targets or by repression of posttranscriptional modification of mRNAs. MiRNAs are found to regulate the differentiation, development, function and stress responsive growth of cardiac cells. Their role and association with several disease progressions is of interest in recent years. Our interest is to study their role in cardiac hypertrophy (characterized by increased cell size, protein synthesis and reactivation of gene pathways). Therefore, we analyzed their features using a dataset (# ≈1400 #) of potential intronic and 3'UTR targeted miRNAs from known cardiac marker genes. We report 10 uncharacterized miRNAs regulating cardiac marker genes during cardiac hypertrophy and other cardiac diseases.