Molecular allergy diagnostics and improving allergen-specific immunotherapy in the cases of sensitization to weed pollen

Abstract

The results of a study of data from 60 patients with allergic rhinitis, sensitized to weed pollen, are presented. According to the results of skin tests, 20 % showed monosensitization to ragweed, 20 % - oligosensitization to ragweed and wormwood, 60 % - polysensitization to weeds, timothy grass, birch. Specific antibodies to the major ragweed allergen (IgE nAmb a1) has been detected in 81.7 % of patients, wormwood (IgE nArt v1) - in 26.7 %, timothy grass (IgE rPhl p1.5) - in 10.0 %, birch (IgE Bet v1) - in 6.7 %. Molecular component-separated allergy diagnostics may result in changed allergen-specific immunotherapy program in 43.3 % of patients sensitized to weed pollen.