Working in "NK mode": Natural killer group 2 member D and natural cytotoxicity receptors in stress-surveillance by γδ T cells

6Citations
Citations of this article
26Readers
Mendeley users who have this article in their library.

Abstract

Natural killer cell receptors (NKRs) are germline-encoded transmembrane proteins that regulate the activation and homeostasis of NK cells as well as other lymphocytes. For γδ T cells, NKRs play critical roles in discriminating stressed (transformed or infected) cells from their healthy counterparts, as proposed in the "lymphoid stress-surveillance" theory. Whereas the main physiologic role is seemingly fulfilled by natural killer group 2 member D, constitutively expressed by γδ T cells, enhancement of their therapeutic potential may rely on natural cytotoxicity receptors (NCRs), like NKp30 or NKp44, that can be induced selectively on human Vd1+ T cells. Here, we review the contributions of NCRs, NKG2D, and their multiple ligands, to γδ T cell biology in mouse and human.

Cite

CITATION STYLE

APA

Silva-Santos, B., & Strid, J. (2018, April 24). Working in “NK mode”: Natural killer group 2 member D and natural cytotoxicity receptors in stress-surveillance by γδ T cells. Frontiers in Immunology. Frontiers Media S.A. https://doi.org/10.3389/fimmu.2018.00851

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free