Functional Genomics and CRISPR Applied to Cardiovascular Research and Medicine

Abstract

Novel genetic loci associated with cardiovascular diseases will continue to emerge through GWAS in diverse populations. The post-GWAS functional studies will dedicate to delineating the causal genetic variants and genes and the underlying biological mechanisms. Novel functional genomic technologies at single-cell and single-molecule level will further reveal cell type- specific regulatory mechanisms.56The promise of functional genomics is to understand the function of all components of the genome, and ultimately translate genetic findings toward clinical applications in the diagnosis and treatment of both rare and common cardiovascular diseases.