Potential COX2 mediated Therapeutic effect of Ciprofloxacin

Abstract

Fluoroquinolones (FQs) are broad-spectrum, synthetic antibiotics that inhibit bacterial DNA synthesis. FQs directly block DNA synthesis in the bacterial cell via inhibition the activity of two tetrameric, ATP-dependent, homologous type II topoisomerase enzymes: topoisomerase II-called DNA gyrase and topoisomerase IV. FQs are also active against eukaryotic topoisomerase II. This property results in inhibition of this enzyme and pro apoptotic effects on mammalian tumor cell lines, including human cells, and creates the possibility of using FQs as potential anticancer drugs. In one study, it was found that ciprofloxacin induced the production of prostaglandin E2 in monocytes in a concentration-dependent manner.