Highly selective determination of pioglitazone in urine and pharmaceutical formulations by novel PVC-membrane sensors

Abstract

Novel simple, selective and sensitive poly(vinyl chloride) membrane sensors are developed for the determination of pioglitazone in biological samples (urine) and pharmaceutical preparations. Potentiometric measurements were based on iodobismuthite-drug ion-pair as novel electroactive materials incorporating a plasticized PVC membrane with o-nitrophenyl octyl ether or dioctyl phthalate. Each sensor was conditioned for at least two days in 0.1 M drug solution before use. It exhibited fast and stable Nernstian response for pioglitazone over the concentration range of 1.0x10-7-1.0x10-2 M, pH range of 3.0-7.0 pioglitazone sensors. Results with an average recovery not more than 100.4% and a mean standard deviation less than 1.0% of the nominal were obtained for the two sensors. The sensors showed reasonable selectivity towards investigated drugs in presence of many cations. © 2014 The Authors. Published by ESG.