Abstract
Simultaneous multi-element imaging using NanoSIMS (nano-scale secondary ion mass spectrometry), exploiting the novel combination of 195Pt and 15N in platinum-am(m)ine antitumour drugs, provides information on the internalisation and subcellular localisation of both metal and ligands, and allows identification of ligand exchange. © 2013 The Royal Society of Chemistry.
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CITATION STYLE
Wedlock, L. E., Kilburn, M. R., Liu, R., Shaw, J. A., Berners-Price, S. J., & Farrell, N. P. (2013). NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound. Chemical Communications, 49(62), 6944–6946. https://doi.org/10.1039/c3cc42098a
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