Association of killer cell immunoglobulin- like receptor genes in iranian patients with rheumatoid arthritis

13Citations
Citations of this article
15Readers
Mendeley users who have this article in their library.

Abstract

Objectives Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by persistent synovitis, ultimately leading to cartilage and bone degeneration. Natural Killer cells and CD28 null T-cells are suspected as role players in RA pathogenesis. These cells are similar in feature and function, as they both exert their cytotoxic effect via Killer Cell Immunoglobulin- Like Receptors (KIR) on their surface. KIR genes have either an inhibitory or activating effect depending on their intracytoplasmic structure. Herein we genotyped 16 KIR genes, 3 pseudo genes and 6 HLA class † genes as their corresponding ligands in RA patients and control subjects. Methods In this case-control study, KIR and HLA genes were genotyped in 400 RA patients and 372 matched healthy controls using sequence-specific primers (SSP-PCR). Differences in the frequency of genes and haplotypes were determined by χ test. Results KIR2DL2, 2DL5a, 2DL5b and activating KIR: KIR2DS5 and 3DS1 were all protective against RA. KIR2DL5 removal from a full Inhibitory KIR haplotype converted the mild protection (OR = 0.56) to a powerful predisposition to RA (OR = 16.47). Inhibitory haplotype No. 7 comprising KIR2DL5 in the absence of KIR2DL1 and KIR2DL3 confers a 14-fold protective effect against RA. Conclusion Individuals carrying the inhibitory KIR haplotype No. 6 have a high potential risk for developing RA.

Cite

CITATION STYLE

APA

Nazari, M., Mahmoudi, M., Rahmani, F., Akhlaghi, M., Beigy, M., Azarian, M., … Mansouri, R. (2015). Association of killer cell immunoglobulin- like receptor genes in iranian patients with rheumatoid arthritis. PLoS ONE, 10(12). https://doi.org/10.1371/journal.pone.0143757

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free